Endocrine Abstracts

Introduction: Elevated activity and expression of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) are associated with the development of obesity and metabolic syndrome. This enzyme is responsible for majority of the extra-adrenal production of glucocorticoids. It regenerates active cortisol from biologically inactive cortisone. Human 11β-HSD1 also reversibly catalyzes the inter-conversion of 7α-hydroxy- and 7β-hydroxy-DHEA into 7-oxo-DHEA. In order to...

Objective: Prevalence of childhood obesity has been increasing steadily. Unfortunately, only a small number of European countries have functional system to monitor this problem. Since it is very important to have comparable data on the international level, Childhood obesity surveillance initiative has been established by WHO Europe in 2006. The objective of the initiative is to monitor prevalence of obesity and factors related to obesity among children (nutrition habits, physi...